Of the three occupants of the van, one man was seriously injured. Another man suffered minor injuries. Both have been taken to hospital. The driver of the van, a man in his 30s, was arrested in connection with the collision and remains in custody at this time.
The HGV driver was not injured.
Anyone who witnessed the collision, or the vehicles involved prior to it, is asked to contact North Yorkshire Police on 101, or email firstname.lastname@example.org, quoting reference 12200085067.
The road was closed until about 8.30am this morning while emergency services worked at the scene.