The collision involved a white Mercedes van, a light blue Toyota Prius and a green Vauxhall Astra.
Both the driver of the Toyota, a woman from Ripon, and the driver of the Vauxhall, a man aged 79 from Harrogate, were trapped needing to be cut from their vehicle by fire and rescue crews.
The occupants were transported to hospital via road and air ambulance suffering with head, chest, back and neck injuries.
It is not believed the driver of the Mercedes van was injured.
The road reopened at 12:15pm with all the vehicles needing recovery.
If you can assist with this investigation, contact North Yorkshire Police on 101, press option 2 and ask for Mark Mullins.
Or email firstname.lastname@example.org quoting reference NYP – 29112013 – 0164
Photo credit: Nathan Miller.