The collision involved a white Mercedes van, a light blue Toyota Prius and a green Vauxhall Astra.
It occurred at a junction on the A59/ Skipton road which was just past the Nelson Inn travelling towards Skipton.
The occupants were transported to hospital via road and air ambulance suffering with head, chest, back and neck injuries.
It is not believed the driver of the Mercedes van was injured.
The road reopened at 12:15pm with all the vehicles needing recovery.
If you can assist with this investigation, contact North Yorkshire Police on 101, press option 2 and ask for Mark Mullins.
Or email email@example.com quoting reference NYP – 29112013 – 0164
Photo credit: Nathan Miller.