The incident, which involved several people, took place at 4.17 am today (Friday, December 11, 2015) on Cambridge Road.
A man in his early 20s was taken to Leeds General Infirmary with head injuries. A second man, also in his early 20s, was also treated for wounds to his back.
A 19-year-old man was arrested on suspicion of actual bodily harm and criminal damage and remains in custody at this time.
Anyone with information is asked to call 101, select option 2 and ask for the Harrogate Investigation Hub.
Please quote reference number 12150219251.