It happened at 5.40pm on Skipton Road at the junction of Coppice Way, and involved a car, a van and a motorcycle.
The motorcycle, a silver 500cc Kawasaki, and the car, a grey Volvo XC90 were travelling up Skipton Road, from the direction of the New park roundabout when they collided at the junction with Coppice Way. The motorcycle left the road and collided with the van, a Citroen Berlingo, which was parked on a driveway.
The 44yr old female driver of the Volvo was shaken but otherwise uninjured.
The 28yr old male rider of the motorcycle was taken by Yorkshire Air Ambulance to the Leeds General Infirmary with serious, but not believed to be life threatening injuries.
Anyone who witnessed the collision, or who saw the Volvo or Kawasaki Motorcycle prior to the collision, is asked to contact police.
Dial 101, press 2 and ask to speak to TC 1295 Rob Roberts from the Road Policing Unit at Harrogate.
Please quote reference number NYP-31032016-0424 when passing on information about the incident.