It occurred between 4:45 pm on Saturday 1 November and 6.00am on Sunday 2 November 2014, from a business on Hornbeam Park.
The thieves stole several thousand pounds worth of chocolate made by Confection By Design and Serious Sweet Co.
Detective Constable Sam Harding, of Harrogate CID, said: Due to the amount of chocolate and sweets which has been stolen, I believe that a large vehicle will have been used to transport it.
If you saw any suspicious activity in the Hornbeam Park area around the time of the burglary I urge you to come forward and contact the police straight away.
I am also keen to speak to anyone who is offered chocolate and sweets bearing either the brands Confection by Design, Serious Sweets, Ultimate English or Ultimate Collection in unusual circumstances and ask them to get in touch as soon as possible.
Anyone with information which could help this enquiry should contact Harrogate CID on 101, select option 2 and ask for Sam Harding. Alternatively, information can be emailed to Sam.harding @northyorkshire.pnn.police.uk
Or call Crimestoppers anonymously on 0800 555111, quoting reference number 12140189450.