The centre is opposite the Mercedes Benz garage, just off the A61 – between Pannal and Harrogate.
The stolen watches are by various makes including Cartier, Breitling, Rolex and Omega and range in value from a few hundred pounds to £7,000 each.
Police are appealing for any information about the thefts, in particular, anyone who may have been offered similar watches for sale in the Leeds or Harrogate area over the last few days.
They also urge anyone who witnessed the break-in or saw any suspicious activity in the area of the centre to contact them.
Anyone with any information is asked to contact North Yorkshire Police on 101, select option 2 and ask for Harrogate CID.
Alternatively, you can pass information anonymously to Crimestoppers on 0800 555 111.