The collision, which occurred two miles north of the village at 2pm today (Tuesday 7 August 2012), involved a silver Rover 45 which was travelling towards York and a black Vauxhall Meriva heading towards Easingwold.
A 57-year-old man from York, who was driving the Rover, suffered serious injuries and was taken by air ambulance to Leeds General Infirmary where he currently being treated.
The occupants in Vauxhall, a man, woman and two children, were taken to York District Hospital with minor injuries.
If you witnessed the collision or saw either of the vehicles prior to the incident, I urge you to contact the police as soon as possible.
I am particularly keen to speak with the driver of a white van which was following the Rover shortly before the collision. I believe that he or she may have vital information to assist the investigation.
The road currently remains closed and is likely to be for some time. Local diversions are in place while police investigate the scene and the vehicles are recovered.
Anyone who can assist officers with this investigation is asked to contact North Yorkshire Police on 101, select option 2 and ask for Ian McKenzie. Alternatively you can email information to email@example.com