The collision occurred at around 3.30pm today, Tuesday 19 April, and involved three vehicles, a black Ford Ka, a black Vauxhall Corsa and a black Kawasaki motorcycle.
The rider of the motorcycle, a man in his 50s, was airlifted to Leeds General Infirmary with serious injuries, where he sadly died.
The driver of the Ford Ka sustained minor injuries and the driver of the Corsa was uninjured.
The motorcycle was travelling towards Harrogate and the two cars were travelling in the opposite direction.
The road was closed to allow collision investigators to examine the scene, it was reopened at around 6.30pm.
Police are appealing for anyone who saw any of the vehicles prior to the collision, or anyone who witnessed the crash, to contact them.
Please contact Sergeant Ian Pope at Harrogate Roads Policing Unit on 0845 60 60 247.