The collision occurred shortly before 5.30am at Stump Cross near Boroughbridge and involved an HGV lorry and a black Skoda Fabia.
The driver of the Skoda, a 38 year old man from the Cleveland area, was sadly pronounced dead at the scene.
The road has now fully re-opened.
Officers investigating the collision are appealing for any witnesses to come forward.
Dial 101, press 2 and ask to speak to the Major Collision Investigation Team or email MCIT@northyorkshire.pnn.police.uk
Please quote incident number NYP-21112-17-0038 when passing on information.